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Article

Arylamine N-Acetyltransferases in Mycobacteria

1 Jul 2008

Abstract excerpt

Polymorphic Human arylamine N-acetyltransferase (NAT2) inactivates the anti-tubercular drug isoniazid by acetyltransfer from acetylCoA. There are active NAT proteins encoded by homologous genes in mycobacteria including M. tuberculosis, M. bovis BCG, M. smegmatis and M. marinum. Crystallographic structures of NATs from M. smegmatis and M. marinum, as native enzymes and with isoniazid bound share a similar fold...

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PMID: 18680471
DOI: 10.2174/138920008784892100

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