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Article

Allele-selective effect of PA28 in MHC class I antigen processing.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2008

Yamano Taketoshi, Sugahara Hidetoshi, Mizukami Shusaku, Murata Shigeo, Chiba Tomoki, Tanaka Keiji, Yui Katsuyuki, Udono Heiichiro

Abstract excerpt

PA28 is an IFN-gamma-inducible proteasome activator and its genetic ablation causes complete loss of processing of certain Ags, but not all of them. The reason why this occurs and how PA28 influences the formation of peptide repertoires for MHC class I molecules remains unknown. In this study, we show the allele-specific role of PA28 in Ag processing. Retrovirus-transduced overexpression of PA28alpha decreased...

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Identifiers

PMID: 18641301
DOI: 10.4049/jimmunol.181.3.1655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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