Article

Spliced peptides and cytokine driven changes in the immunopeptidome of melanoma

2019-05-02

Abstract excerpt

<h4>Summary</h4> Antigen-recognition by CD8 + T cells is governed by the pool of peptide antigens presented on the cell surface in the context of HLA class I complexes. Recent studies have shown not only a high degree of plasticity in the immunopeptidome, but also that a considerable fraction of all presented peptides is generated through proteasome-mediated splicing of non-contiguous regions of proteins to form...

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Literature Corpus work: 0ed2fefa-5556-5297-96a3-99032f6bd29f
DOI: 10.1101/623223

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