Article
Aldosterone synthase gene polymorphism as a determinant of atrial fibrillation in patients with heart failure.
The American journal of cardiology - 1 Aug 2008
Amir Offer, Amir Ruthie E, Paz Hagar, Mor Roi, Sagiv Michael, Lewis Basil S
Abstract excerpt
We analyzed the possible association between aldosterone synthase (CYP11B2) T-344C polymorphism, which is associated with increased aldosterone activity, and the prevalence of atrial fibrillation (AF) in 196 consecutive patients who had symptomatic systolic heart failure (HF; left ventricular ejection fraction <40%) for > or =3 months before recruitment. Genomic DNA was extracted from peripheral blood leukocytes...
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