Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects.

Genetic epidemiology - 1 Jan 2009

Shibata Kyoko, Diatchenko Luda, Zaykin Dmitri V

Abstract excerpt

In genetic mapping of complex traits, scored haplotypes are likely to represent only a subset of all causal polymorphisms. At the extreme of this scenario, observed polymorphisms are not themselves functional, and only linked to causal ones via linkage disequilibrium (LD). We will demonstrate that due to such incomplete knowledge regarding the underlying genetic mechanism, the variance of a trait may become...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Epistasis, Genetic
Share to Likelihood Functions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

Share to Models, Statistical

Share to Molecular Epidemiology

Share to Pain Threshold

Share to Quantitative Trait, Heritable

Source

Open in PubMed Open full text

Identifiers

PMID: 18636529
DOI: 10.1002/gepi.20358
PMCID: PMC2700858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects.PMID 18636529Read ↗

Score tests for association between traits and haplotypes when linkage phase is ambiguous.Semantic proximity Read ↗

Evaluating associations of haplotypes with traits.Semantic proximity Read ↗

Including measured genotypes in statistical models to study the interplay of multiple factors affecting complex traits.Semantic proximity Read ↗

Mixed modeling and multiple imputation for unobservable genotype clusters.Semantic proximity Read ↗

Maximum likelihood estimation of haplotype effects and haplotype-environment interactions in association studies.Semantic proximity Read ↗

Haplotypes of common SNPs can explain missing heritability of complex diseasesSemantic proximity Read ↗

Power and sample size for testing associations of haplotypes with complex traits.Semantic proximity Read ↗

Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous.Semantic proximity Read ↗

Joint linkage and segregation analysis under multiallelic trait inheritance: simplifying interpretations for complex traits.Semantic proximity Read ↗

Robust testing of haplotype/disease association.Semantic proximity Read ↗

The use of haplotypes in the identification of interaction between SNPs.Semantic proximity Read ↗

Haplotype-based association analysis in cohort studies of unrelated individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.