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Article

Joint linkage and segregation analysis under multiallelic trait inheritance: simplifying interpretations for complex traits.

Genetic epidemiology - 1 May 2010

Rosenthal Elisabeth A, Wijsman Ellen M

Abstract excerpt

Identification of the genetic basis of common traits may be hindered by underlying complex genetic architectures that are inadequately captured by existing models, including both multiallelic and multilocus modes of inheritance (MOI). One useful approach for localizing genes underlying continuous complex traits is the joint oligogenic linkage and segregation analysis implemented in the package Loki. The method...

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PMID: 20091797
DOI: 10.1002/gepi.20490
PMCID: PMC2914272

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