Article
Glutathione S-transferase polymorphisms are not associated with population pharmacokinetic parameters of busulfan in pediatric patients.
Therapeutic drug monitoring - 1 Aug 2008
Zwaveling Juliette, Press Rogier R, Bredius Robbert G M, van Derstraaten Tahar R J H M, den Hartigh Jan, Bartelink Imke H, Boelens Jaap Jan, Guchelaar Henk-Jan
Abstract excerpt
High busulfan exposure is associated with increased toxicity, for example veno-occlusive disease, whereas low exposure results in less efficacy such as lower engraftment rates. Despite adjusting dose to body weight, interindividual variability in pharmacokinetics and thus drug exposure remained rather large. In this report, the contribution of genetic polymorphisms in the glutathione-S-transferases (GST) isozymes...
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