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Article

Gender-dependent association of the GNAS1 T393C polymorphism with early aseptic loosening after total hip arthroplasty.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Dec 2008

Bachmann Hagen S, Hanenkamp Sandra, Kornacki Bartlomiej, Frey Ulrich H, Bau Maja, Siffert Winfried, Wedemeyer Christian

Abstract excerpt

The G-protein Galphas is involved in the physiology and pathophysiology of bone. Especially, Galphas is a key regulator of interleukin-6, which is a potent promoter of aseptic loosening. We hypothesized that the common single nucleotide polymorphism GNAS1 T393C could also affect time to aseptic loosening. Caucasian patients were genotyped for the GNAS1 T393C polymorphism. Time and median time to aseptic loosening...

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Identifiers

PMID: 18634020
DOI: 10.1002/jor.20699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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