Article
The T393C polymorphism of the Galphas gene (GNAS1) is associated with the course of Graves' disease.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Jun 2009
Glowacka D, Loesch C, Johnson K T M, Mann K, Esser J, Morgenthaler N G, Siffert W, Schmid K W, Eckstein A K
Abstract excerpt
Genotypes of the T393C SNP of GNAS1, a gene that encodes for the Galphas subunit of G proteins have been significantly associated with the clinical course in a variety of cancers. Since this SNP may also influence the course of Graves' disease (GD) and, especially, Graves' ophthalmopathy (GO), we determined genotype and allele frequency in a series of 359 patients, which were referred to our clinic within 6...
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