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Article

IL-1 β gene (+3954 C/T, exon 5, rs1143634) and NOS2 (exon 22) polymorphisms associate with early aseptic loosening of arthroplasties.

Scientific reports - 1 Nov 2022

López-Anglada Esteban, Collazos Julio, Montes A Hugo, Pérez-Is Laura, Pérez-Hevia Imanol, Jiménez-Tostado Sergio, Suárez-Zarracina Tomás, Alvarez Victoria, Valle-Garay Eulalia, Asensi Víctor

Abstract excerpt

Aseptic prosthetic loosening (APL) and prosthetic joint infections (PJI) are frequent complications of hip and knee implants. Polymorphisms of cytokines and nitric oxide (NO), key inflammatory molecules in APL and PJI pathogenesis, could explain individual susceptibility to these complications. Three cytokines (IL-1-a, IL-1-β, TNF-α) and two nitric oxide synthase (NOS2, NOS3) genes polymorphisms were genotyped in...

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PMID: 36319725
DOI: 10.1038/s41598-022-22693-0
PMCID: PMC9626623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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