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Structural and Functional Characterization of Sapovirus RNA-Dependent RNA Polymerase

23 Nov 2006

Abstract excerpt

Sapoviruses are one of the major agents of acute gastroenteritis in childhood. They form a tight genetic cluster (genus) in the Caliciviridae family that regroups both animal and human pathogenic strains. No permissive tissue culture has been developed for human sapovirus, limiting its characterization to surrogate systems. We report here on the first extensive characterization of the key enzyme of replication,...

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PMID: 17121797
DOI: 10.1128/jvi.01462-06

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