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Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells

17 Mar 2016

Abstract excerpt

The Picornaviridae family comprises a large group of non-enveloped viruses that have a major impact on human and veterinary health. The viral genome contains one open reading frame encoding a single polyprotein that can be processed by viral proteinases. The crucial 3C proteinases (3C(pro)s) of picornaviruses share similar spatial structures and it is becoming apparent that 3C(pro) plays a significant role in the...

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PMID: 26999188
DOI: 10.3390/v8030082

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