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Article

Upstream plasticity and downstream robustness in evolution of molecular networks.

BMC evolutionary biology - 8 Mar 2004

Maslov Sergei, Sneppen Kim, Eriksen Kasper Astrup, Yan Koon-Kiu

Abstract excerpt

BACKGROUND: Gene duplication followed by the functional divergence of the resulting pair of paralogous proteins is a major force shaping molecular networks in living organisms. Recent species-wide data for protein-protein interactions and transcriptional regulations allow us to assess the effect of gene duplication on robustness and plasticity of these molecular networks. RESULTS: We demonstrate that the...

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Identifiers

PMID: 15070432
DOI: 10.1186/1471-2148-4-9
PMCID: PMC385226

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