Article

Single-cell imaging of protein dynamics of paralogs reveals mechanisms of gene retention

2023-11-23

Abstract excerpt

Gene duplication is common across the tree of life, including yeast and humans, and contributes to genomic robustness. In this study, we examined changes in the subcellular localization and abundance of proteins in response to the deletion of their paralogs originating from the whole-genome duplication event, which is a largely unexplored mechanism of functional divergence. We performed a systematic single-cell im...

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Literature Corpus work: 5b6b6915-1e4d-5122-a153-1bb4680fc139
DOI: 10.1101/2023.11.23.568466

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