Article
Slk19-dependent mid-anaphase pause in kinesin-5-mutated cells.
Journal of cell science - 1 Aug 2008
Movshovich Natalia, Fridman Vladimir, Gerson-Gurwitz Adina, Shumacher Inbal, Gertsberg Irena, Fich Alexander, Hoyt M Andrew, Katz Benjamin, Gheber Larisa
Abstract excerpt
We examined spindle elongation in anaphase in Saccharomyces cerevisiae cells mutated for the kinesin-5 motor proteins Cin8 and Kip1. Cells were deleted for KIP1 and/or expressed one of two motor-domain Cin8 mutants (Cin8-F467A or Cin8-R196K, which differ in their ability to bind microtubules in vitro, with Cin8-F467A having the weakest ability). We found that, in kinesin-5-mutated cells, predominantly in kip1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
