Article
Circadian phenotypes of Drosophila fragile x mutants in alternative genetic backgrounds.
Zoological science - 1 Jun 2008
Sekine Tatsumori, Yamaguchi Terumi, Hamano Kunikatsu, Siomi Haruhiko, Saez Lino, Ishida Norio, Shimoda Masami
Abstract excerpt
Drosophila FMR1 mutants are models of human fragile X syndrome. They show a loss of locomotor activity rhythm and severe degradation of eclosion timing. We analyzed the circadian behavior of FMR1 mutants (dfmr1B55) in two genetic backgrounds, yellow white (yw) and Canton S (CS). The arrhythmic phenotype of circadian locomotor activity in constant darkness (DD) did not significantly change in either genetic...
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