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Article

Circadian Rhythm and Sleep Analyses in a Fruit Fly Model of Fragile X Syndrome Using a Video-Based Automated Behavioral Research System.

International journal of molecular sciences - 20 Jul 2024

Milojevic Sara, Ghosh Arijit, Makevic Vedrana, Stojkovic Maja, Capovilla Maria, Tosti Tomislav, Budimirovic Dejan, Protic Dragana

Abstract excerpt

Fragile X syndrome (FXS) is caused by the full mutation in the FMR1 gene on the Xq27.3 chromosome region. It is the most common monogenic cause of autism spectrum disorder (ASD) and inherited intellectual disability (ID). Besides ASD and ID and other symptoms, individuals with FXS may exhibit sleep problems and impairment of circadian rhythm (CR). The Drosophila melanogaster models of FXS, such as dFMR1B55,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39063191
DOI: 10.3390/ijms25147949
PMCID: PMC11277495

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