Article
Understanding fragile X syndrome: insights from animal models.
Cytogenetic and genome research - 1 Jan 2003
Bakker C E, Oostra B A
Abstract excerpt
The fragile X mental retardation syndrome is caused by large methylated expansions of a CGG repeat in the FMR1 gene leading to the loss of expression of FMRP, an RNA-binding protein. FMRP is proposed to act as a regulator of mRNA transport or translation that plays a role in synaptic maturation and function. To study the physiological function of the FMR1 protein, mouse and Drosophila models have been developed....
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