In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans.

doi:10.1158/1055-9965.EPI-08-0832

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Article

In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2009

Doroshyenko Oxana, Fuhr Uwe, Kunz Daria, Frank Dorothee, Kinzig Martina, Jetter Alexander, Reith Yvonne, Lazar Andreas, Taubert Dirk, Kirchheiner Julia, Baum Matthias, Eisenbrand Gerhard, Berger Franz-Ingo, Bertow Daniel, Berkessel Albrecht, Sörgel Fritz, Schömig Edgar, Tomalik-Scharte Dorota

Abstract excerpt

Acrylamide, a potential food carcinogen in humans, is biotransformed to the epoxide glycidamide in vivo. Both acrylamide and glycidamide are conjugated with glutathione, possibly via glutathione-S-transferases (GST), and bind covalently to proteins and nucleic acids. We investigated acrylamide toxicokinetics in 16 healthy volunteers in a four-period change-over trial and evaluated the respective role of...

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Identifiers

PMID: 19190172
DOI: 10.1158/1055-9965.EPI-08-0832

Genes

GSTM1
GSTP1
GSTT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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