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Article

Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1.

The Journal of cell biology - 10 Aug 2009

Nakanishi Shima, Lee Jung Shin, Gardner Kathryn E, Gardner Jennifer M, Takahashi Yoh-hei, Chandrasekharan Mahesh B, Sun Zu-Wen, Osley Mary Ann, Strahl Brian D, Jaspersen Sue L, Shilatifard Ali

Abstract excerpt

Histone H2B monoubiquitination by Rad6/Bre1 is required for the trimethylation of both histone H3K4 and H3K79 by COMPASS and Dot1 methyltransferases, respectively. The dependency of methylation at H3K4 and H3K79 on the monoubiquitination of H2BK123 was recently challenged, and extragenic mutations in the strain background used for previous studies or epitope-tagged proteins were suggested to be the sources of...

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PMID: 19667127
DOI: 10.1083/jcb.200906005
PMCID: PMC2728409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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