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Article

An investigation into CAG repeat length variation and N/C terminal interactions in the T877A mutant androgen receptor found in prostate cancer.

The Journal of steroid biochemistry and molecular biology - 1 Jul 2008

Southwell Jason, Chowdhury Shafinaz F, Gottlieb Bruce, Beitel Lenore K, Lumbroso Rose, Purisima Enrico O, Trifiro Mark

Abstract excerpt

Prostate cancer may progress by circumventing ablation therapy due to mutations in the androgen receptor (AR) gene. The most intensively studied is the T877A mutation in the ligand binding domain (LBD), which causes the AR to become promiscuous, i.e., respond to a number of different ligands. Our investigations have shown that the T877A mutation alters the inverse relationship between CAG repeat length and...

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Identifiers

PMID: 18619542
DOI: 10.1016/j.jsbmb.2008.04.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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