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Article

Human androgen receptor gene ligand-binding-domain mutations leading to disrupted interaction between the N- and C-terminal domains.

Journal of molecular endocrinology - 1 Apr 2006

Jääskeläinen J, Deeb A, Schwabe J W, Mongan N P, Martin H, Hughes I A

Abstract excerpt

Most mutations in the androgen receptor (AR) ligand-binding domain (LBD) disrupt binding of the natural ligands: dihydrotestosterone and testosterone. Some AR LBD mutations do not affect ligand binding but they disrupt androgen-induced interaction of the N-terminal motif FXXLF and C-terminal activation function 2 (AF2). As N-/C-terminal interaction requires binding of agonists that have androgen activity in vivo,...

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PMID: 16595706
DOI: 10.1677/jme.1.01885

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