Article
Induction of mutations in mouse lymphoma L5178Y cells by ethylmethanesulphonate, benzidine and benzo[a]pyrene.
Mutagenesis - 1 Jan 1990
Henderson L, Ransome S, Brabbs C, Tinner A, Davies S
Abstract excerpt
As part of the third UKEMS collaborative trial, the induction of mutations in mouse lymphoma L5178Y cells was analysed by an agar cloning method. The method used was based on the published methods of Clive and co-workers and Amacher and co-workers. Mutations at the thymidine kinase (tk) locus were analysed following exposure to ethylmethanesulphonate (EMS) in the absence of S9 mix, benzo[a]pyrene (B[a]P) in the...
Topics
- Animals
- Benzidines
- Benzo(a)pyrene
- Biotransformation
- Cell Survival
- Ethyl Methanesulfonate
- Hypoxanthine Phosphoribosyltransferase
- Leukemia L5178
- Mice
- Microsomes, Liver
- Multicenter Studies as Topic