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Article

Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.

BMC medical genetics - 10 Jul 2008

Kerber Richard A, Amos Christopher I, Yeap Beow Y, Finkelstein Dianne M, Thomas Duncan C

Abstract excerpt

BACKGROUND: Modern approaches to identifying new genes associated with disease allow very fine analysis of association and can be performed in population based case-control studies. However, the sibpair design is still valuable because it requires few assumptions other than acceptably high penetrance to identify genetic loci. METHODS: We conducted simulation studies to assess the impact of design factors on...

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Identifiers

PMID: 18616822
DOI: 10.1186/1471-2350-9-64
PMCID: PMC2488325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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