Article
Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.
BMC medical genetics - 10 Jul 2008
Kerber Richard A, Amos Christopher I, Yeap Beow Y, Finkelstein Dianne M, Thomas Duncan C
Abstract excerpt
BACKGROUND: Modern approaches to identifying new genes associated with disease allow very fine analysis of association and can be performed in population based case-control studies. However, the sibpair design is still valuable because it requires few assumptions other than acceptably high penetr...
Topics
- Colonic Neoplasms
- Computer Simulation
- Genetic Linkage
- Genetic Predisposition to Disease
- Genotype
- Humans
- Models, Genetic
- Penetrance
- Regression Analysis
- Sample Size