Article
Genetic and epigenetic analysis of the VHL gene in gastric cancers.
Acta oncologica (Stockholm, Sweden) - 1 Jan 2008
Cao Zhang, Song Jae Hwi, Kim Chang Jae, Cho Yong Gu, Kim Su Young, Nam Suk Woo, Lee Jung Young, Park Won Sang
Abstract excerpt
The von Hippel-Lindau tumor suppressor gene (VHL), which is located on chromosome 3p25, plays an important role in tumorigenesis, particularly in tumor growth and vascularization. Mutations of the VHL gene have been observed in the hereditary VHL syndrome and a variety of other sporadic cancers. In this study, in order to investigate whether the VHL gene is involved in gastric carcinogenesis, we have examined the...
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