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Article

VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumors.

Endocrine-related cancer - 1 Dec 2009

Schmitt A M, Schmid S, Rudolph T, Anlauf M, Prinz C, Klöppel G, Moch H, Heitz P U, Komminoth P, Perren A

Abstract excerpt

A small subset of familial pancreatic endocrine tumors (PET) arises in patients with von Hippel-Lindau syndrome and these tumors may have an adverse outcome compared to other familial PET. Sporadic PET rarely harbors somatic VHL mutations, but the chromosomal location of the VHL gene is frequently deleted in sporadic PET. A subset of sporadic PET shows active hypoxia signals on mRNA and protein level. To identify...

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Source

Identifiers

PMID: 19690016
DOI: 10.1677/ERC-08-0297

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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