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Article

Reconsideration of biallelic inactivation of the VHL tumour suppressor gene in hemangioblastomas of the central nervous system.

Journal of neurology, neurosurgery, and psychiatry - 1 May 2001

Gläsker S, Bender B U, Apel T W, van Velthoven V, Mulligan L M, Zentner J, Neumann H P

Abstract excerpt

OBJECTIVES: Cerebellar haemangioblastoma occurs sporadically or as a component tumour of autosomal dominant von Hippel-Lindau disease. Biallelic inactivation of the VHL tumour suppressor gene, which is located on chromosome 3p, has been shown to be involved in the pathogenesis of both tumour enti...

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Share to Cerebellar Neoplasms
Share to Chromosomes, Human, Pair 3
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11309459
DOI: 10.1136/jnnp.70.5.644
PMCID: PMC1737358

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11309459-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Reconsideration of biallelic inactivation of the VHL tumour suppressor gene in hemangioblastomas of the central nervous system.PMID 11309459Read ↗

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Molecular genetic analysis of the von Hippel-Lindau disease tumor suppressor gene in familial and sporadic cerebellar hemangioblastomas.Semantic proximity Read ↗

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Sporadic hemangioblastomas are characterized by cryptic VHL inactivation.Semantic proximity Read ↗

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Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours.Semantic proximity Read ↗

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Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors.Semantic proximity Read ↗

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Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas.Semantic proximity Read ↗

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