Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of von hippel-lindau mutations with comparative genomic hybridization in sporadic and hereditary hemangioblastomas: possible genetic heterogeneity.

Journal of neurosurgery - 1 Oct 2002

Gijtenbeek Johanna M M, Jacobs Bram, Sprenger Sandra H E, Eleveld Marc J, van Kessel Ad Geurts, Kros Johan M, Sciot Raf, van Calenbergh Frank, Wesseling Pieter, Jeuken Judith W M

Abstract excerpt

OBJECT: Hemangioblastomas (HBs) occur sporadically or as a manifestation of von Hippel-Lindau (VHL) disease. In the majority of VHL-related HBs, inactivation of the VHL tumor suppressor gene (TSG), which is located on chromosome 3p25-26, is found. The VHL gene is assumed to be involved also in the development of sporadic HBs. In a previous study of chromosomal aberrations of sporadic HBs, multiple chromosomal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebellar Neoplasms
Share to Chromosomes, Human, Pair 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Hemangioblastoma

Share to Ligases

Share to Nucleic Acid Hybridization

Share to von Hippel-Lindau Disease

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 12405390
DOI: 10.3171/jns.2002.97.4.0977

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of von hippel-lindau mutations with comparative genomic hybridization in sporadic and hereditary hemangioblastomas: possible genetic heterogeneity.PMID 12405390Read ↗

Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system.Semantic proximity Read ↗

Sporadic hemangioblastomas are characterized by cryptic VHL inactivation.Semantic proximity Read ↗

Reconsideration of biallelic inactivation of the VHL tumour suppressor gene in hemangioblastomas of the central nervous system.Semantic proximity Read ↗

Molecular genetic analysis of the von Hippel-Lindau disease tumor suppressor gene in familial and sporadic cerebellar hemangioblastomas.Semantic proximity Read ↗

Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas.Semantic proximity Read ↗

Somatic mutational landscape in von Hippel-Lindau familial hemangioblastoma.Semantic proximity Read ↗

Clinical and molecular features of familial and sporadic cases of von Hippel-Lindau disease from Mexico.Semantic proximity Read ↗

Central nervous system manifestations in VHL: genetics, pathology and clinical phenotypic features.Semantic proximity Read ↗

Differential Genetic Alterations in von Hippel-Lindau Syndrome-Associated and Sporadic Pheochromocytomas1Semantic proximity Read ↗

Somatic mutations in VHL germline deletion kindred correlate with mild phenotype.Semantic proximity Read ↗

Ocular manifestations of von Hippel-Lindau disease: clinical and genetic investigations.Semantic proximity Read ↗

Somatic mosaicism in von Hippel-Lindau Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.