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Article

The implications of human metabolic network topology for disease comorbidity.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2008

Lee D-S, Park J, Kay K A, Christakis N A, Oltvai Z N, Barabási A-L

Abstract excerpt

Most diseases are the consequence of the breakdown of cellular processes, but the relationships among genetic/epigenetic defects, the molecular interaction networks underlying them, and the disease phenotypes remain poorly understood. To gain insights into such relationships, here we constructed...

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Share to Comorbidity
Share to Epigenesis, Genetic
Share to Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metabolic Diseases

Share to Metabolic Networks and Pathways

Share to Metabolism, Inborn Errors

Share to Models, Biological

Share to Phenotype

Source

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Identifiers

PMID: 18599447
DOI: 10.1073/pnas.0802208105
PMCID: PMC2481357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18599447-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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