Article
The implications of human metabolic network topology for disease comorbidity.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2008
Lee D-S, Park J, Kay K A, Christakis N A, Oltvai Z N, Barabási A-L
Abstract excerpt
Most diseases are the consequence of the breakdown of cellular processes, but the relationships among genetic/epigenetic defects, the molecular interaction networks underlying them, and the disease phenotypes remain poorly understood. To gain insights into such relationships, here we constructed a bipartite human disease association network in which nodes are diseases and two diseases are linked if mutated...
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