Influence of functional interleukin 10/tumor necrosis factor-alpha polymorphisms on interferon-alpha, IL-10, and regulatory T cell population in patients with systemic lupus erythematosus receiving antimalarial treatment.

Abstract excerpt

OBJECTIVE: As interleukin 10 (IL-10)/tumor necrosis factor-alpha (TNF-alpha) polymorphisms have been shown to influence TNF-alpha inhibition and clinical response to antimalarial treatment in patients with systemic lupus erythematosus (SLE), we investigated involvement of these variants in antimalarial effects on cytokine serum levels and regulatory T cell population (Treg). METHODS: The alleles present at -308...

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