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Article

IL‐10 promoter haplotype influence on interferon treatment response in multiple sclerosis

3 Feb 2005

Abstract excerpt

The level of interleukin-10 (IL-10) expression is related to polymorphisms -1082 (G/A), -819 (T/C) and -592 (A/C) in the promoter region of the IL-10 gene, which constitute three haplotypes, GCC, ATA, and ACC. The ATA (a non-GCC) haplotype, which is associated with low IL-10 expression, has been shown to improve interferon (IFN) treatment response in hepatitis C. We analysed the distribution of IL-10 promoter...

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PMID: 15693804
DOI: 10.1111/j.1468-1331.2004.01102.x

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