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Article

Effects of brain-derived neurotrophic factor-catecholamine-O-methyltransferase gene interaction on schizophrenic symptoms.

Neuroreport - 16 Jul 2008

Han Doug Hyun, Park Doo Byung, Choi Tae Young, Joo So Youn, Lee Mi Kyung, Park Bo Rae G, Nishimura Ryoji, Chu Chung-Chou, Renshaw Perry F

Abstract excerpt

The methionine variant of Val66Met brain-derived neurotrophic factor BDNF met and catecholamine-O-methyltransferase (COMT L) is associated with a deficit in attention and aggravation of delusions in schizophrenia. We hypothesized that the BDNF-COMT gene interaction would affect the symptoms and cognition in schizophrenia. Ninety-six schizophrenic patients and 79 control participants were recruited. The patients...

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Source

Identifiers

PMID: 18596619
DOI: 10.1097/WNR.0b013e32830867ad

Genes

BDNF
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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