Article
Prolonged replication of a type 1 vaccine-derived poliovirus in an immunodeficient patient.
Journal of clinical microbiology - 1 Oct 1998
Kew O M, Sutter R W, Nottay B K, McDonough M J, Prevots D R, Quick L, Pallansch M A
Abstract excerpt
VP1 sequences were determined for poliovirus type 1 isolates obtained over a 189-day period from a poliomyelitis patient with common variable immunodeficiency syndrome (a defect in antibody formation). The isolate from the first sample, taken 11 days after onset of paralysis, contained two poliov...
Topics
- Adult
- Amino Acid Sequence
- Base Sequence
- Capsid
- Capsid Proteins
- Child
- Evolution, Molecular
- Feces
- Follow-Up Studies
- Genetic Variation
- Humans
- Immunologic Deficiency Syndromes
- Male
- Molecular Sequence Data
- Phylogeny
- Poliomyelitis
- Poliovirus
- Poliovirus Vaccine, Oral