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Article

Evolution of the Ly49 and Nkrp1 recognition systems.

Seminars in immunology - 1 Dec 2008

Carlyle James R, Mesci Aruz, Fine Jason H, Chen Peter, Bélanger Simon, Tai Lee-Hwa, Makrigiannis Andrew P

Abstract excerpt

The Ly49 and Nkrp1 loci encode structurally and functionally related cell surface proteins that positively or negatively regulate natural killer (NK) cell-mediated cytotoxicity and cytokine production. Yet despite their clear relatedness and genetic linkage within the NK gene complex (NKC), these two multi-gene families have adopted dissimilar evolutionary strategies. The Ly49 genes are extremely polymorphic and...

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Identifiers

PMID: 18595730
DOI: 10.1016/j.smim.2008.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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