Article
Complex variation in the KLRA (LY49) immunity-related genomic region in horses.
HLA - 1 Sept 2020
Futas Jan, Oppelt Jan, Janova Eva, Musilova Petra, Horin Petr
Abstract excerpt
Natural killer (NK) cells play important roles in innate and adaptive immunity, as well as in the reproduction of placental mammals. Ly49 (KLRA) molecules represent a lectin-like type of NK cell receptor encoded within a complex genomic region, the NK cell complex. In rodents and horses, an expansion of the genes encoding Ly49 receptors leading to the formation of a gene family was observed. High sequence...
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