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Article

Mouse Nkrp1-Clr gene cluster sequence and expression analyses reveal conservation of tissue-specific MHC-independent immunosurveillance.

PloS one - 1 Jan 2012

Zhang Qiang, Rahim Mir Munir A, Allan David S J, Tu Megan M, Belanger Simon, Abou-Samra Elias, Ma Jaehun, Sekhon Harman S, Fairhead Todd, Zein Haggag S, Carlyle James R, Anderson Stephen K, Makrigiannis Andrew P

Abstract excerpt

The Nkrp1 (Klrb1)-Clr (Clec2) genes encode a receptor-ligand system utilized by NK cells as an MHC-independent immunosurveillance strategy for innate immune responses. The related Ly49 family of MHC-I receptors displays extreme allelic polymorphism and haplotype plasticity. In contrast, previous BAC-mapping and aCGH studies in the mouse suggest the neighboring and related Nkrp1-Clr cluster is evolutionarily...

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Identifiers

PMID: 23226525
DOI: 10.1371/journal.pone.0050561
PMCID: PMC3514311

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Source receipt: pubmed, retrieved 7 Sept 2026.

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