Article
Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status.
World journal of gastroenterology - 21 Jun 2008
Mokarram Pooneh, Naghibalhossaini Fakhraddin, Saberi Firoozi Mehdi, Hosseini Seyed Vahid, Izadpanah Ahmad, Salahi Heshmetalah, Malek-Hosseini Seyed Ali, Talei Abdoulrasool, Mojallal Mehra
Abstract excerpt
AIM: To evaluate joint effects of Methylentetra-hydrofolate reductase (MTHFR) C677T genotypes, and serum folate/vitamin B(12) concentrations on promoter methylation of tumor-associated genes among Iranian colorectal cancer patients. METHODS: We examined the associations between MTHFR C677T genoty...
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