Article
Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation: indicators of tumor staging and metastasis in adenocarcinomatous sporadic colorectal cancer in Indian population.
PloS one - 1 Jan 2013
Sinha Rupal, Hussain Showket, Mehrotra Ravi, Kumar R Suresh, Kumar Kapil, Pande Pankaj, Doval Dinesh Chandra, Basir Seemi Farhat, Bharadwaj Mausumi
Abstract excerpt
OBJECTIVE: Colorectal cancer (CRC) development involves underlying modifications at genetic/epigenetic level. This study evaluated the role of Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation together/independently in sporadic CRC in Indian population and correlation with clinicopathological variables of the disease. METHODS: One hundred and twenty four consecutive surgically resected...
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