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Article

Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism and folate intake in esophageal squamous cell carcinoma.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Chen Jing, Huang Zhi-Jie, Duan Yu-Qin, Xiao Xin-Rong, Jiang Jian-Qing, Zhang Ru

Abstract excerpt

AIM: The present case-control study was conducted to explore the association of MTHFR gene polymorphism and relations of P16, MGMT and HMLH1 to MTHFR and folate intake. METHODS: A total of 257 cases of esophageal squamous cell carcinoma confirmed by histopathological examination were collected. Genotyping of P16, MGMT and HMLH1 was accomplished by methylation-specific polymerase chain reaction (PCR) after sodium...

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Share to Carcinoma, Squamous Cell
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Modification Methylases

Share to DNA Repair Enzymes

Share to Esophageal Neoplasms

Share to Folic Acid

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to MutL Protein Homolog 1

Source

Identifiers

PMID: 23244153
DOI: 10.7314/apjcp.2012.13.10.5303

Genes

MGMT
MTHFR

Variants

Provenance

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