Article
Restoration of normal bone development by human homologue of collagen type II (COL2A1) gene in Col2a1 null mice.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 1999
Rani P U, Stringa E, Dharmavaram R, Chatterjee D, Tuan R S, Khillan J S
Abstract excerpt
Development of the vertebrate skeleton is a highly complex process in which collagen type II plays a vital role in the formation of long bones via endochondral ossification. Collagen type II, which is encoded by a single COL2A1/ Col2a1 gene, is the most abundant structural protein in the cartilage matrix, where it undergoes complex interactions with several other proteins. The sequence of mature collagen type II...
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