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Article

Gene expression variation increase in trisomy 21 tissues.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2008

Chou Ching Yu, Liu Li Yu, Chen Chien Yu, Tsai Cheng Hsien, Hwa Hsiao Lin, Chang Li Yun, Lin Yi Shing, Hsieh Fon Jou

Abstract excerpt

Congenital development disorders with variable severity occur in trisomy 21. However, how these phenotypic abnormalities develop with variations remains elusive. We hypothesize that the differences in euploid gene expression variation among trisomy 21 tissues are caused by the presence of an extra copy of chromosome 21 and may contribute to the phenotypic variations in Down syndrome. We used DNA microarray to...

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PMID: 18594911
DOI: 10.1007/s00335-008-9121-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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