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Article

Specific transcriptional changes in human fetuses with autosomal trisomies

1 Jan 2007

Abstract excerpt

Among full autosomal trisomies, only trisomies of chromosome 21 (Down syndrome), 18 (Edwards syndrome) and 13 (Patau syndrome) are compatible with postnatal survival. But the mechanisms, how a supernumerary chromosome disrupts the normal development and causes specific phenotypes, are still not fully explained. As an alternative to gene dosage effect due to the trisomic chromosome a genome-wide transcriptional...

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PMID: 18253026
DOI: 10.1159/000112058

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