Article
Gene expression variation in Down's syndrome mice allows prioritization of candidate genes.
Genome biology - 1 Jan 2007
Sultan Marc, Piccini Ilaria, Balzereit Daniela, Herwig Ralf, Saran Nidhi G, Lehrach Hans, Reeves Roger H, Yaspo Marie-Laure
Abstract excerpt
BACKGROUND: Down's syndrome (DS), or trisomy 21, is a complex developmental disorder that exhibits many clinical signs that vary in occurrence and severity among patients. The molecular mechanisms responsible for DS have thus far remained elusive. We argue here that normal variation in gene expression in the population contributes to the heterogeneous clinical picture of DS, and we estimated the amplitude of this...
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