Article

Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21

2017-01-17

Abstract excerpt

Trisomy of chromosome 21, the genetic cause of Down syndrome, has the potential to alter expression of genes on chromosome 21, as well as other locations throughout the genome. These transcriptome changes are likely to underlie the Down syndrome clinical phenotypes. We have employed RNA-seq to undertake an in-depth analysis of transcriptome changes resulting from trisomy of chromosome 21, using induced pluripotent...

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Literature Corpus work: e5fa8536-b044-5500-b2f8-a9520b71b447
DOI: 10.1101/100859

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