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Article

Genome-wide expression analysis of cultured trophoblast with trisomy 21 karyotype

28 Jun 2007

Abstract excerpt

BACKGROUND: The pathologic features of Down syndrome are assumed to be the result of over-expression of genes located on chromosome 21 and/or a more global transcriptional misregulation that crosses chromosomal borders. METHODS: To address this issue, four RNA samples from trisomy 21 placentas and four samples from normal first trimester pregnancies were analyzed using Affymetrix U95v2 microarray. Statistical and...

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PMID: 17635843
DOI: 10.1093/humrep/dem214

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