Article

A New Approach to The Pathogenesis of Down Syndrome: An Integrated Quantitative Neuro-Transcriptome Analysis of Several Brain Areas in Human Trisomy 21.

2021-02-10

Abstract excerpt

<h4>Background: </h4> Although Down syndrome (DS) is a trisomy of chromosome 21 being the most frequent human chromosomal disorder mainly associated with variable levels of intellectual disability and other dysfunctions, the only dose disbalance effect would not enough to explain its genetic and functional complexity neurophenotype. In this context, we aimed to analyze and compare the disruption of transcriptome o...

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Literature Corpus work: 917797cb-329b-5f13-8f7e-54d74fa2c7f3
DOI: 10.21203/rs.3.rs-176627/v1

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