Article
Angiogenesis correlates with vascular endothelial growth factor expression but not with Ki-ras oncogene activation in non-small cell lung carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 1997
Tsao M S, Liu N, Nicklee T, Shepherd F, Viallet J
Abstract excerpt
A total of 195 non-small cell lung carcinoma (NSCLC) specimens were studied for the presence of mutations in their ras family genes, for tumor vascularity, and for their immunostaining pattern with an antibody to vascular endothelial growth factor (VEGF). ras mutation was found in 37 of 104 (34.6...
Topics
- Alleles
- Bronchi
- Capillaries
- Carcinoma, Non-Small-Cell Lung
- Cell Line, Transformed
- DNA Mutational Analysis
- DNA, Neoplasm
- Endothelial Growth Factors
- Enzyme Activation
- Genes, ras
- Humans
- Lung Neoplasms
- Lymphokines
- Neoplasm Proteins
- Neovascularization, Pathologic
- Prognosis
- Proto-Oncogene Proteins p21(ras)
- RNA, Messenger