Article
The p53 Homologue ΔNp63α Interacts with the Nuclear Factor-κB Pathway to Modulate Epithelial Cell Growth
1 Jul 2008
Abstract excerpt
The p53 homologue DeltaNp63alpha is overexpressed and inhibits apoptosis in a subset of human squamous cell carcinomas (SCC). Here, we report that in normal keratinocytes overexpressing DeltaNp63alpha and in human squamous carcinoma cells, DeltaNp63alpha physically associates with phosphorylated, transcriptionally active nuclear c-Rel, a nuclear factor-kappaB family member, resulting in increased c-Rel nuclear...
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