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Article

Tumor-Specific p73 Up-regulation Mediates p63 Dependence in Squamous Cell Carcinoma

1 Oct 2006

Abstract excerpt

p63 is essential for normal epithelial development and is overexpressed in the vast majority of squamous cell carcinomas (SCC). Recent work had shown that DeltaNp63alpha is essential for survival of SCC cells, raising the possibility that the p63 pathway may be an attractive therapeutic target in these tumors. Nevertheless, it is unknown whether a therapeutic window exists for inhibiting p63 in tumor cells versus...

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PMID: 17018588
DOI: 10.1158/0008-5472.can-06-1619

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