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Article

ΔNp63α Repression of the <i>Notch1</i> Gene Supports the Proliferative Capacity of Normal Human Keratinocytes and Cervical Cancer Cells

4 May 2010

Abstract excerpt

The p53 family member p63 is a master regulator of epithelial development. One of its isoforms, DeltaNp63alpha, is predominantly expressed in the basal cells of stratified epithelia and plays a fundamental role in control of regenerative potential and epithelial integrity. In contrast to p53, p63 is rarely mutated in human cancers, but it is frequently overexpressed in squamous cell carcinomas (SCC). However, its...

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PMID: 20442293
DOI: 10.1158/0008-5472.can-09-4063

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